Lead researcher position in cancer immunotherapy

By opening an Inserm chair, the INCIT Laboratory will be able to recruit an emerging leader in innovative adoptive cell transfer approaches. The candidate will demonstrate advanced skills in receptor design, T cell biology and engineering techniques to implement the next generation of immunotherapy approaches in cancers. The project will aim to use gene editing techniques and synthetic biology to design highly sensitive and multispecific T cell receptors for ACT. Cutting-edge methodology will be employed to deliver receptors into primary T cells. Receptor signaling and its regulation in modified T cells, modulation of functional avidity and synapse formation and T cell functions will be analyzed in vitro. Consequences on T cell fate, susceptibility to exhaustion and antitumor efficacy will be determined in pre-clinical mouse models. Multi-specific strategies to address target-antigen loss and/or down modulation and approaches to provide adequate co-stimulation to preserve transferred-T cell functions will also be investigated. In addition to the expertise of the INCIT unit teams in Immunotherapy and the support provided by this scientific and technological environment, the chair holder will also benefit from existing clinical networks coordinated by INCIT teams and by their collaborators, from the technological platforms associated to the Unit within a Federative research structure (SFR Santé), and international collaborative networks involving INCIT members. The candidate will demonstrate strong emphasis on translating research findings to the clinic.

Supporting Documents for Lead researcher position in cancer immunotherapy

Company

Founded in 1964, Inserm is a public scientific and technological institute which operates under the joint authority of the French Ministries of Health and Research. The institute is dedicated to biomedical research and human health, and is involved in the entire range of activities from the laboratory to the patient’s bedside. It also partners with the most prestigious research institutions in the world that are committed to scientific challenges and progress in these fields. Inserm brings together 15,000 researchers, engineers, technicians and administrative staff, all with one shared objective: improve health by advancing knowledge about living organisms and diseases, developing innovative treatment modalities and conducting research on public health.

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